Splet09. mar. 2024 · The mechanisms regulating AMPA receptor trafficking have evoked great interest through the decades. Recent studies show that in the brain, AMPA receptors make complexes with transmembrane AMPA ... Splet08. avg. 2014 · The N-methyl-d-aspartate receptor (NMDAR) plays various physiological and pathological roles in neural development, synaptic plasticity and neuronal cell death.It is composed of two GluN1 and two GluN2 subunits and, in the neonatal hippocampus, most synaptic NMDARs are GluN2B-containing receptors, which are gradually replaced with …
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Splet13. apr. 2024 · Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice ... (2024) AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking. Cell Mol Life Sci … SpletAbstract. Phosphorylation of GluA1, a subunit of AMPA receptors (AMPARs), is critical for AMPAR synaptic trafficking and control of synaptic transmission. cGMP-dependent protein kinase II (cGKII) mediates this phosphorylation, and cGKII knockout (KO) affects GluA1 phosphorylation and alters animal behavior. smart life orange
Dynamic imaging of AMPA receptor trafficking in vitro and in vivo
SpletThe function and membrane trafficking of AMPARs is regulated by multiple interacting proteins, as well as by posttranslational modifications, including phosphorylation, palmitoylation, and ubiquitination ().In particular, phosphorylation of GluA1 at S845 by cyclic-AMP–dependent protein kinase (PKA) and at S831 by calcium/calmodulin … Splet01. jul. 2010 · Thus, an active area of investigation is the discovery of accessory proteins that regulate AMPA receptor trafficking and biophysical properties. One decade ago, pioneering studies identified the transmembrane protein stargazin as a critical regulator of synaptic targeting of AMPA receptors in cerebellar granule neurons. Splet12. nov. 2013 · Although AMPA receptors do not bind directly to AP-4, their somatodendritic trafficking is regulated by forming a tripartite complex with STG and μ4 (ref. 14).Therefore, we next used a co ... smart life organization