Web3 Oct 2006 · The rupture of the thin fibrous cap overlying the necrotic core of a vulnerable plaque is the principal cause of acute coronary syndrome. It has been widely assumed that plaque morphology is the major determinant of clinical outcome (1–6).Several pathological studies of ruptured plaques have provided morphological descriptions of the high-risk, or … WebThe morphological characteristics have been identified in several human histopathological and in vivo studies, and include: 1) a large lipid core (≥40% plaque volume) composed of free cholesterol crystals, cholesterol esters, and oxidized lipids impregnated with tissue factor, 2) a thin fibrous cap depleted of smooth muscle cells and collagen ...
Detection of lipid pool, thin fibrous cap, and inflammatory …
Web22 Jul 2024 · Our results demonstrate that treatment of fat-fed Ldlr −/− mice with established atherosclerosis with S2P-siCamk2g NPs silences lesional macrophage CaMKIIγ and promotes efferocytosis, increases fibrous cap thickness, and inhibits atherosclerotic plaque necrosis. This study demonstrates the use of siRNA-containing NPs to silence … WebSenescent cells (SNCs) degenerate the fibrous cap that normally prevents atherogenic plaque rupture, a leading cause of myocardial infarction and stroke. ... Collectively, these results indicate that senolysis is not only capable of blocking fibrous cap thinning, but can, in extremely thin-capped fibroatheromas, thicken a thin fibrous cap by ... super chewer reviews
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WebVascular tissue samples are continuously processed and characterized to assess tissue morphology, histological quality, cellular composition, inflammation, calcification, neovascularization, and the content of elastin and collagen fibers. Webclassified as fibrous plaques, fibrous cap atheromas, thin-cap atheromas, and healed ruptures, and macrophage infiltration was assessed semiquantitatively. Results—Median serum homocysteine postmortem as a result of acute thrombus was 10.4 mol/L (P0.4 versus controls), Web23 Sep 2024 · Vulnerable plaques most commonly have a large plaque burden with a well-formed necrotic core and thin fibrous cap and are metabolically active. Perivascular … super chewer puppy