Web29 Sep 2024 · Pseudocholinesterase (butyrylcholinesterase) deficiency is an inherited or acquired condition in which the serum pseudocholinesterase levels are absent or lower than normal. The enzyme is produced by the liver; decreased levels of the enzyme in an individual cause increased sensitivity to anesthetic agents, like succinylcholine and mivacurium. WebKnown pseudocholinesterase deficiency (eg, organophosphate poisoning or congenital enzyme deficiency), which risks prolonged… Preoperative evaluation for anesthesia for …
Anticholinesterases and anticholinergic drugs - Oxford Academic
Web1 Apr 2024 · Succinylcholine is a skeletal muscle relaxant used while performing medical procedures under general anesthesia, including tracheal intubation, mechanical … Webcholinesterase deficiency limits the use of certain muscle relaxants. The authors describe a patient receiving ECT for treatment of his depression, who also possessed an unsuspected pseudocholinesterase deficiency. This was diagnosed after the patient was given succinylcholine, did not spontaneously recover motor function, and eventually required … construction worker death houston
Pseudocholinesterase deficiency - About the Disease
Pseudocholinesterase (soo-doe-koh-lin-ES-tur-ays) deficiency is a rare disorder that makes you sensitive to certain muscle relaxants ― succinylcholine or mivacurium ― used during general anesthesia. Mivacurium is no longer available in the United States but is sometimes used in other countries. Succinylcholine … See more For most people with pseudocholinesterase deficiency, no signs or symptoms of the condition occur until you get the muscle relaxant succinylcholine. This … See more Your risk of having pseudocholinesterase deficiency is higher if you or a first-degree relative, such as a parent, child or sibling, has: 1. A gene change … See more If you have pseudocholinesterase deficiency, your body has no pseudocholinesterase or an amount that's too low. This enzyme is needed to break down (metabolize) drugs known as choline esters. … See more If you have a family history of pseudocholinesterase deficiency or have a family member who had any problem with anesthesia, tell your … See more WebWhen succinylcholine and mivacurium are applied on patients with cholinesterase-deficiency during general anesthesia, prolonged postoperative asphyxia occurs, which is … Web1 Oct 2004 · It also inactivates other esters on which acetylcholinesterase has little or no effect, for example succinylcholine, mivacurium, ester local anaesthetics, diamorphine and aspirin. ... Prolonged use of ecothiopate and physostigmine eye drops can lead to acquired cholinesterase deficiency and prolonged block from neuromuscular blocking drugs that ... construction worker in malay