WebShumiya cataract rat (SCR) is a hereditary cataractous rat strain that develops cataract at approximate 11 weeks of age . Lss gene is mutated in SCR and is the major gene for cataract onset [ 19 ]. In humans, two distinct homozygous LSS missense mutations (W581R and G588S) happen in two families with extensive congenital cataracts, which impairs key … WebJul 4, 2024 · The Shumiya cataract rat (SCR) is a hereditary cataractous rat strain, which is classed as two models (non-cataract type, SCR-N, and cataractous type, SCR-C) . SCR-N (ctr1 × ctr1, Ctr2 × Ctr2), without the mutations causing premature cataracts, maintains a transparent lens, although slight lens structure collapse was observed at 8–12 weeks of …
Comparison of the Mechanisms of Cataract Development …
WebWe previously found that the increases in Ca 2+ content in the lenses of three hereditary cataract model rats, UPL rat (UPLR), Shumiya cataract rat (SCR) and Ihara cataract rat (ICR), are inhibited by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase, and that the mechanisms of Ca 2+ enhancement in these rat models differ. In this study, we … WebJul 10, 2003 · Methods Selenite cataract was induced in Sprague–Dawley rats by five subcutaneous injections of sodium ... activity in selenite nuclear cataract 20 and Shumiya cataract 21 in rat. ... songs with empty in title
Histopathological study of hereditary cataractous lenses in SCR …
WebWe demonstrate a delaying effect of deep-sea drinking water (DDW) containing enhanced magnesium ion (Mg 2 +) and calcium ion (Ca 2 +) concentrations on cataract … WebThe role of proteolytic enzymes in Shumiya cataract rats in alterations to lens proteins during cataract formation was studied immunohistochemically using antibodies against … WebAug 20, 2024 · The lens of cataract rats had α-A crystallin expression levels increased by 35% when compared to the control (Fig. 2E). ... Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. J. Clin. Invest., 116 (2006), pp. 395-404. CrossRef View Record in Scopus Google Scholar songs with end in the title