Irf3 transcription factor
WebJun 19, 2012 · Given that IRF3 acts as a transcription activator for promoters of genes encoding type I interferons but not for the Il12b promoter, it will be useful to explore the molecular mechanism by... WebIRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. Following virus infection, IRF-3 is posttranslationally modified by protein phosphorylation at multiple serine and threonine residues, located in the carboxy-terminus of IRF-3.
Irf3 transcription factor
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WebNov 1, 2012 · IFN regulatory factor 3 (IRF3) regulates early type I IFNs and other genes involved in innate immunity. We have previously shown that cells undergoing an endoplasmic reticulum (ER) stress response called the unfolded protein response produce synergistically augmented IFN-β when stimulated with pattern recognition receptor … WebDec 4, 2024 · IRF3 and IRF5 are phosphorylated by protein kinases, which are activated by signalling pathways of pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) that signal via TRIF (TLR3 and TLR4) and MyD88 (e.g. …
WebInterferon regulatory factor 3 (IRF3) is a key transcription factor activated in response to virus infection and is largely responsible for establishing an antiviral state in the infected... WebAutophagic degradation of IRF3 induced by the small-molecule auranofin inhibits its transcriptional and proapoptotic activities Autophagic degradation of IRF3 induced by the small-molecule auranofin inhibits its transcriptional and proapoptotic activities J Biol Chem. 2024 Oct 5;297 (5):101274. doi: 10.1016/j.jbc.2024.101274. Online ahead of print.
WebOct 15, 2024 · Transcription factors for expression of IRF3 engage its gene locus located on human chromosome 19q13.3–13.4 . The structural gene is composed of eight exons, which include a 5′UTR. Several laboratories uncovered critical domains of … WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other …
WebMay 31, 2024 · IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which is ubiquitously expressed in a variety of cells.
WebSep 19, 2013 · IRF3 is a constitutively expressed transcription factor that resides in the cytoplasm and dimerizes and translocates to the nucleus upon phosphorylation ().Phosphorylated IRF3 induces IFN-β during viral infection, but may also contribute to inflammatory cytokine response to LPS ().IRF3 also promotes apoptosis in virus-infected … howald electroWebJul 25, 2024 · The discovery Interferon-regulatory factor 3 (IRF3) and IRF7 are the two pivotal transcriptional factors that directly control the production of IFN-α and IFN-β, determining the antiviral... howald curlingWebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … howald cliffordWebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … how many hours can a commercial pilot flyWeb1 day ago · STING recruitment of TBK1 and IRF3 results in IRF3 phosphorylation by TBK1 and IRF3 55 nuclear translocation[18, 19]. Activated STING also activates IKK and the NF-κB family of 56 transcription factors[20], which with IRF3, activate expression of type I IFN and subsequently 57 ISGs. ISGs include an array of anti-HIV restriction factors ... howald caroleWebMar 29, 2024 · IRF3 is activated by phosphorylation (by kinases TBK1 and IKKε), promoting dimerization, nuclear translocation, association with the co-activator CREB-binding protein … how alcohol works in our bodyWebUsing cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. … how alcohol withdrawal kills