WebJan 7, 2024 · A combination of α splitting and fixed sequence testing can also be done. As numbers of endpoints increases the numbers of ways to allocate the α across endpoints also increases. The specific α ... WebNov 1, 2001 · This paper introduces a generalized fixed sequence procedure whose critical values are defined by using a function of the numbers of rejections and acceptances, and which allows follow-up hypotheses to be tested even if some earlier hypotheses are not rejected. 3. PDF. View 2 excerpts, cites methods.
The fallback procedure for evaluating a single family of hypotheses
WebFixed sequence procedures are unlike stepwise methods, such as the Holm procedure [4] and Hochberg procedure [5], where the ordering and testing of the hypotheses are … WebFeb 1, 2005 · A fixed sequence Bonferroni procedure for testing multiple endpoints. Pharma. Stat. 2 : 211 – 215 . [CSA] [CROSSREF] [CrossRef], [Web of Science ®]View all references). Several examples are... how to say josiah in english
On generalized fixed sequence procedures for controlling the FWER
WebDec 30, 2015 · We also prove that each generalized fixed sequence procedure can be described as a specific closed testing procedure. Through simulation studies and a clinical trial example, we compare the power performance of these proposed procedures with those of the existing FWER controlling procedures. WebOct 10, 2024 · Figure 1 Testing hierarchy shows fixed sequence of analyses used for primary and secondary efficacy end points in healing and maintenance phases. ∗The hypothesis testing of the primary end point of the maintenance phase was adjusted using Hochberg’s multiple comparisons method to control the overall 0.05 level of significance … WebJun 21, 2007 · 1 must be rejected to test the hypotheses in F 2; a powerful procedure to use would be the intersection–union test of Berger [7]. This test tests each hypothesis in F 1 at the a level. Hypotheses in F 2 can be tested using any multiple test that controls the FWER for that family at the a level, e.g. the Holm test [12] or the Hochberg test north kiteboarding board shorts