Dichloromethylene-bisphosphonate
WebJan 23, 2003 · Recently, considerable progress has been made in elucidating the molecular mechanism of action of bisphosphonates and, not surprisingly, it has been found to differ between the 2 structural subgroups. 5 Etidronate and clodronate appear to form cytotoxic ATP-analogues after internalization by mammalian cells. By contrast, the nitrogen … Webthe bacteria with the bisphosphonate DMDP (dichloromethylene diphosphonic acid) causes a stronger synergistic effect together with copper than polyP with copper. Bisphosphonates are pyrophosphate analogs, comprising a carbon atom (P-C-P) instead of an oxygen atom (P-O-P) between the two phosphorus atoms (reviewed in [38]).
Dichloromethylene-bisphosphonate
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WebClodronate (dichloromethylene bisphosphonate) inhibits the activity of osteoclasts, thereby preventing bone resorption in disorders characterized by excessive bone loss. … WebClodronate (dichloromethylene bisphosphonate) inhibits the activity of osteoclasts, thereby preventing bone resorption in disorders characterized by excessive bone loss. Intravenously injected clodronate encapsulated in liposomes is also known to inactivate phagocytic cells in spleen and liver in vivo. The macrophage suppressive effect of ...
WebSep 14, 1994 · We have developed a macrophage 'suicide' technique, using the liposome mediated intracellular delivery of dichloromethylene-bisphosphonate (Cl2MBP or … WebData on the long‐term treatment of myeloma bone disease with bisphosphonates are scanty. In a prospective pilot trial we evaluated the effect of long‐term parenteral …
WebDDT (bis [4-chlorophenyl]-1,1,1-trichloroethane) is a persistent insecticide that was used worldwide from the mid 1940s until its ban in the USA and other countries in the … WebSigma-Aldrich. 233183. Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem. A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast …
WebClodronate (dichloromethylene bisphosphonate) accumualtes extensively in the bone by binding to apatite crystals. We found recently that the drug also accumulates in the spleen and, to a lesser extent, in the liver of mice and rats. In the present study, the role of macrophages in soft tissue accumulation was studied in mice by autoradiography ...
WebClodronate (dichloromethylene bisphosphonate) accumulates extensively in bone by binding to hydroxyapatite crystals. In an hypo-osmotic vehicle, it accumulates also in the … imperium chibougamauWebPurpose. Non-nitrogen-containing bisphosphonates, such as clodronate (dichloromethylene bisphosphonate), appear to act as prodrugs, their active form being the AppCp-type analogues of ATP. To further elucidate this, we examined the cellular uptake of clodronate and intracellular accumulation of the metabolite of clodronate … lite flight helicoptersWebFeb 16, 2024 · Dichlorphenamide side effects. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a … imperium chiropractic ladysmith wiWebTetrahydrate dichloromethylene-bisphosphonate CH12Cl2O10P2 CID 129735069 - structure, chemical names, physical and chemical properties, classification, patents, … lite flightWebDisplacement of platelets from blood to spleen following intravenous injection of liposomes encapsulating dichloromethylene bisphosphonate Displacement of platelets from blood to spleen following intravenous injection of liposomes encapsulating dichloromethylene bisphosphonate Authors M Shibazaki 1 , M Nakamura , Y Nitta , Y Endo Affiliation imperium city namesWebJul 9, 1993 · Synthesis of phenyl substituted bisphosphonates and crystal structures and characterization of Cd complexes of (dichloromethylene)bisphosphonic acid phenyl and alkyl ester derivatives Jonna Jokiniemi , J. Vepsäläinen , … lite flight softballs teeWebJul 3, 2024 · Bisphosphonates are a group of drugs that intervene in the bone resorption process, producing cellular death of osteoclasts. These drugs are used for skeletal conditions, such as osteoporosis in humans, and are available for veterinary medical use. lite flight helicopter tours