WebNov 1, 2009 · Bioconjugates of cypate are not toxic to animals up to 10 μmol/kg, and Cyp-GRD (cypate conjugated with a linear hexapeptide, GRDSPK) is not toxic to the α v β 3-integrin (ABI)-positive tumor cell line, A549, in culture up to a concentration of 100 μM (approximately 0.1 mg/mL). 63,64 In general, cypate is considered a “biocompatible” … WebAug 15, 2014 · The synthesis of cypate-labeled collagen peptide was straightforward by using standard peptide synthesis and coupling methods (). 26 For cypate 3-THP, the carboxylic acid group on cypate was conjugated to the ɛ-amino groups of Lys in the THP backbone.Through self-assembly of three cypate-labeled collagen sequences, the THP …
Cypate and Cypate-Glucosamine as Near-Infrared …
WebCypate-Conjugated Porous Upconversion Nanocomposites for Programmed Delivery of Heat Shock Protein 70 Small Interfering RNA for Gene Silencing and Photothermal Ablation Article Mar 2016 Lu Wang... WebJan 20, 2024 · The preparation process of Cypate was based on reported work . The synthetic route of preparing F68-Cy is shown in Fig. 1B. Cypate (0.56 g, 0.90 mmol) was dissolved in DMF (20 mL). EDCI (0.19 g, 1.00 mmol), NHS (0.12 g, 1.00 mmol) and Pluronic F68 (1.55 g, 0.18 mmol) were added sequentially. The mixture was stirred for 48 h at … orange and black football scarf
Lu Wang
WebThe combination therapy of cancer can be achieved via co-delivery of varying therapeutic molecules in one system. Here, we developed a … WebOct 15, 2024 · Cypate, IR780, and HITC are monomeric tricarbocyanines, while cypate-3 and HIDC are dicarbocyanines. LS301 is a tumor-avid peptide-cypate conjugate. To determine the point of dimerization, we performed 2D NMR analysis. Proton integration of cypate spectra showed seven protons in the polymethine chain of cypate (Figure S5–S6). WebThe conjugated cypate moieties in the cores of CCL micelles resulted in photothermal temperature increase and reactive oxygen species (ROS) generation under 805 nm near infrared (NIR) laser irradiation. The cytotoxicity of CCL micelles was investigated with and without NIR irradiation. A significant synergistic effect of photothermal therapy ... orange and black dance costumes