WebMar 1, 2024 · CTGF expression is principally regulated at the levels of transcription, and its promoter contains a number of binding-sites for transcription factors such as Smads. 15 We recently demonstrated that LPA-induced CTGF expression by mesothelial cells is dependent on LPA 1-MRTF-SRF pathway, and that pharmacological inhibition of the … WebNational Center for Biotechnology Information
Effect of LPA on CTGF expression in MCT cells. CTGF and …
WebTogether with its downstream mediator CTGF (connective tissue growth factor), TGF-β1 stimulates production of collagen and extracellular matrix and causes thickening of the GBM, resulting in podocyte detachment and apoptosis. ... Autotaxin is the enzyme that generates LPA and this molecule has potent pro-fibrotic effects to induce epithelial ... WebIf you have any further questions visit our Contact Us tab. Open Office hours will be on Friday, May 27, from 12-1 PM. Join the Conversation! If you are a CT farmer of any size … how far from melbourne to sydney driving
Lysophosphatidic acid upregulates connective tissue …
Web5 . refers to populations sharing a particular characteristic, as well as geographic communities, that have been . systematically denied a full opportunity to participate in … WebMar 27, 2015 · The graphs summarize quantification of multiple experiments with LPA-stimulated cells set to 1 in each experiment: cellular CTGF: n = 2 ± half range; secreted CTGF control: n = 3, secreted CTGF LPA … WebApr 1, 2024 · Effect of lysophosphatidic acid (LPA) on fibrotic growth factor expression in the small airway epithelial basal cells (SAE BC). Primary SAE BC from each of 3 non-smoking individuals were plated in triplicate in the presence or absence of 1.0 μg/ml LPA and evaluated for expression of connective tissue growth factor (CTGF), endothelin-1 … hierarchy softmax