Cst fam134b

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August undefined, 2024

WebJan 13, 2024 · FAM134B forms oligomers that are required for ER membrane scission and ER-phagy A. Endogenous FAM134B forms oligomers. FAM134B knockout (KO) or wild-type (WT) 293T cells were treated with 1 μM of Thapsigargin (Tg) for different time, and the cell lysates were prepared and analyzed by Western blot. WebFAM134B contains a conserved LC3 interacting domain (LIR) that facilitates binding to LC3 and GABARAP family members and targets impaired ER to the autophagosome for degradation by ER-phagy (2). ... Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products ...

Differential expression of full-length and NH2 terminally …

WebFeb 21, 2024 · FAM134B controls ER turnover by specific binding to microtubule-associated protein 1 light chain 3B (MAP1LC3B), which in turn binds to the phagophore membrane … WebPolyclonal Antibody for studying FAM134B. Cited in 3 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and … flint michigan murder rate 2021

FAM134B oligomerization drives endoplasmic reticulum membrane scission ...

WebApr 18, 2024 · Here we report that in cancer cells, hypoxia-induced ER stress activates ER-phagy through the ER-phagy receptor FAM134B. Upon hypoxic stress, FAM134B is included in a complex with the ER chaperone ... WebMar 29, 2024 · Fam134b is an oncogene that plays a crucial role in hepatocellular carcinoma via the Akt signaling pathway. FAM134B could play crucial roles in the … WebFAM134B (family with sequence similarity 134, member B), also referred to as JK-1 and RETREG1, is a cis-Golgi endoplasmic reticulum (ER) transmembrane protein that plays a role in ER homeostasis and may … flint michigan news sources

FAM134B-Mediated ER-Phagy in Mg2+-Free Solution …

FAM134B Antibody (#61011) Datasheet with Images …

WebJun 15, 2024 · FAM134B is a member of the reticulon-homology-domain-containing FAM134 family and is mainly localized to the edges of the ER sheets. FAM134B binds MAP1LC3B via its LC3 interacting region (LIR) and at the same time to fragmented ER sheets and coalesces them into vesicles, which are subsequently degraded by lysosomes. WebPolyclonal Antibody for studying FAM134B. Cited in 3 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, FAM134B Antibody (CST #61011) is … flint michigan netflixWebApr 11, 2024 · Crucially, to confirm that endogenous FAM134B flux follows a similar trend to the overexpressed reporter, we looked at FAM134B localization in PDAC cells upon BafA1 treatment (Figure 4D). Indeed, FAM134B puncta accumulation after autophagy block indicates high basal turnover rate of the receptor in line with our observation with the … flint michigan modular homes

"WebFeb 19, 2024 · FAM134B was the first and so far the best characterized ER-phagy receptor (Khaminets et al, 2015). FAM134B is an intramembrane ER-resident protein that contains a LIR domain and a reticulon homology domain (RHD), which consists of two membrane-embedded hydrophobic regions bridged by a flexible cytoplasmic linker ... " - Cst fam134b

Cst fam134b

FAM134B Antibody Cell Signaling Technology

WebAug 24, 2024 · Several ER surface receptors, including FAM134B, reticulon 3L (RTN3L), Sec62, and CCPG1, have been shown to contain conserved LC3-interacting regions (LIRs) that can act as specific autophagy receptors to allow portions of the larger ER network to be shunted to core autophagy pathways ( Khaminets et al., 2015; Fumagalli et al., 2016; … WebJul 8, 2024 · The endoplasmic reticulum (ER) autophagy receptor FAM134B contains an LIR motif that can bind to Atg8s, but whether it can differentially bind to the two …

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WebCommunity School 134 is a NYC DOE public school in District 12, Bronx.

WebDec 14, 2024 · FAM134B has also been associated with different cancers, although its exact role remains elusive. We report here that the FAM134B gene encodes not one but … WebDec 14, 2024 · FAM134B (also called RETREG1) is a critical gene for neuronal survival. FAM134B loss-of-function mutations cause hereditary sensory and autonomic neuropathy type II, and its knockdown results in structural alterations of the cis -Golgi compartment, inducing apoptosis in some primary dorsal root ganglion neurons ( 25 ).

WebDec 2, 2024 · FAM134B was also called JK-1, encoding a newly identified Golgi resident protein. It has been reported participating in turnover of ER membranes, tumor inhibition, and lipid homeostasis 10 - 13. FAM134B might play a functional role in fat deposition, as it has been shown that FAM134B is a positive regulator of lipid deposition in preadipocytes … WebJun 23, 2024 · The recent identification of FGF/TFEB/FAM134B signaling event represents the first study that implicates the role of TFEB in ER-phagy and its physiological relevance during skeletal development in ...

WebFeb 19, 2024 · FAM134B was the first and so far the best characterized ER-phagy receptor (Khaminets et al, 2015). FAM134B is an intramembrane ER-resident protein that contains a LIR domain and a reticulon homology …

WebMay 17, 2024 · Four ER-resident proteins (FAM134B, CCPG1, SEC62, and RTN3) have been identified as ER-resident cargo receptors, which contain LC3-interacting regions. In this study, we identified an N … greater nowheresWebOct 4, 2016 · FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga Abhilash I. Chiramel, Jonathan D. Dougherty, Vinod Nair, Shelly J. Robertson, Sonja M. Best greater nottingham mapWebJun 3, 2015 · These data demonstrate that FAM134B is an ER-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (ER-phagy). Notably, this … greater nottingham strategic plan broxtoweWebRespond to Notice CP134B. First, order the Account Transcripts for ALL time periods from the IRS. Then compare your deposits with the Account Transcripts. If you use a payroll … greater nottingham strategic plan timetableWebFAM134B (E8Y9R) Rabbit mAb Cell Signaling Technology Monoclonal Antibody for studying FAM134B. Validated for WB, IP, IF. Highly specific and rigorously validated in-house, FAM134B (E8Y9R) Rabbit Monoclonal Antibody (CST #83414) is ready to ship. Go to your regional site? Would you like to visit your country specific website? YESNO flint michigan obitsWebDec 16, 2024 · The Fam134b gene, located on chromosome 5p15.1, was first identified as a regulator of the malignant phenotype and a downstream molecule of δ-catenin in esophageal squamous cell carcinoma (Tang et al., 2007). However, in colon cancer, FAM134B inhibits the migration of tumor cells (Kasem et al., 2014a, b). flint michigan movie about water crisisWebJun 3, 2015 · ER-bound FAM134B interacts with a protein called LC3 in phagophores through an LIR domain, leading to engulfment of ER fragments by autophagosomes. Mochida et al . 2 report that Atg39 and Atg40 ... flint michigan no grocery