WebSep 1, 2024 · Birthe Gericke; Mahdi Amiri; C. Ronald Scott; Hassan Y Naim; Background & aims: Congenital sucrase-isomaltase deficiency (CSID) is a genetic disorder associated with mutations in the sucrase ... WebBirthe Gericke Maren von Köckritz-Blickwede [...] Wolfgang Löscher Significance Located at the apical (blood-facing) site of brain capillary endothelial cells that form the blood–brain barrier...
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WebSource : Birthe Gericke Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous … WebNational Center for Biotechnology Information
WebJan 26, 2016 · Osmotic diarrhea and abdominal pain in humans are oftentimes associated with carbohydrate malabsorption in the small intestine due to loss of function of … WebAuthors Birthe Gericke 1 , Mahdi Amiri 1 , C Ronald Scott 2 , Hassan Y Naim 3 Affiliations 1 Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Germany. 2 Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.
WebAug 3, 2024 · Birthe Gericke, 1, 2 Saskia Borsdorf, 1 Inka Wienböker, 1, 2 Andreas Noack, 1 Sandra Noack, 3 and Wolfgang Löscher 1, 2 Birthe Gericke 1 Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany WebMay 18, 2024 · Birthe Gericke, Natalie Schecker, +1 author H. Naim Published 18 May 2024 Biology, Chemistry The Journal of Biological Chemistry Sucrase-isomaltase (SI) is an intestinal membrane-associated α-glucosidase that breaks down di- and oligosaccharides to absorbable monosaccharides.
WebMay 5, 2024 · Gericke B, Wienböker I, Brandes G, Löscher W. Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and …
WebBirthe Gericke1 †,Kerstin ... Gericke˜ et al. Fluids Barriers CNS 5 P316 mouse Cldn5 are highly homologou(%)er-ences are mainly localized in transmembrane domain 3 and 4. However, molecular modelling studies show that the differences do not influence their helical structure of the domains and, hence, the claudin-5 function in the ... chinese in newtown ctWebPNAS chinese inn kippaxWebApr 12, 2024 · A feed-forward pathological loop between mutant GCase and α-synuclein accumulation, where increased α-synuclein load inhibits GCase activity and causes lysosomal dysfunction, which in turn reduces degradation of α-synuclein, has been proposed as a mechanism for the increased risk for PD among carriers of mutant GBA alleles. 5 - 8 … grand ole opry daytime tourWebNovel mechanisms such as intra- and intercellular Pgp trafficking and intracellular Pgp-mediated lysosomal sequestration in BBB endothelial cells with subsequent disposal by blood neutrophils are discussed. The blood-brain barrier (BBB) limits the pharmacotherapy of several brain disorders. In addition to the structural and metabolic characteristics of … chinese in nitro wvWebAug 3, 2024 · In cocultures of WT and MDR1-EGFP transduced cells, intercellular Pgp-EGFP trafficking was observed in RBE4 cells as previously reported for hCMEC/D3 … grand ole opry events october 2020WebMay 18, 2024 · Birthe Gericke, Natalie Schecker, +1 author H. Naim; Published 18 May 2024; Biology, Chemistry; The Journal of Biological Chemistry; Sucrase-isomaltase (SI) is an intestinal membrane-associated α-glucosidase that breaks down di- and oligosaccharides to absorbable monosaccharides. SI has two homologous functional subunits (sucrase … grand ole opry factsWebGericke et al. Fluids Barriers CNS 1 1 Page 2 of 22 Background P-glycoprotein (Pgp), the product of the multidrug resist-ance 1 (MDR1) or ABCB1 gene, is an ATP-dependent eux transporter that aects the absorption, distribu-tion, and excretion of various clinically important drugs [1]. At the blood–brain barrier (BBB), which tightly regu- grand ole opry exterior